abstract：OBJECTIVE:To evaluate the usefulness of intervention in drug interactions of antiretroviral drugs with coadministered agents by a clinical pharmacist in outpatient HIV-treatment. METHODS:The study design included two intervention arms (A and B), which were both preceded by a control observation period. In arm A, a com...

journal_title：Journal of clinical pharmacy and therapeutics

authors： de Maat MM,de Boer A,Koks CH,Mulder JW,Meenhorst PL,van Gorp EC,Mairuhu AT,Huitema AD,Beijnen JH

更新日期：2004-04-01 00:00:00

abstract：OBJECTIVE:To evaluate if once-daily dose (ODD) regimens of tobramycin attain pharmacodynamic goals using individualized pharmacokinetic monitoring of critically ill patients with creatinine clearance (Clcr) over 60 mL/min. METHODS:Fifty-one adult critically ill patients treated with intravenous tobramycin with ODD wer...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Peris-Marti JF,Borras-Blasco J,Rosique-Robles JD,Gonzalez-Delgado M

更新日期：2004-02-01 00:00:00

abstract：:When designing studies of the optimal use of antimicrobial drugs, it is important to define at an early stage, which outcome parameters to use. It must be clear to which category a parameter to be measured belongs: the structure, the process or a clinical outcome. Attention must be paid to the measurement scales as we...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Natsch S,Kullberg BJ,Hekster YA,van der Meer JW

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to evaluate the effect of diluent type, storage conditions and the nature of package on the stability of reconstituted Parecoxib sodium for injection (PSI). METHODS:Parecoxib sodium for injection is a lyophilized product for single use. It is intended for the management of acute...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Crane IM,Mulhern MG,Nema S

更新日期：2003-10-01 00:00:00

abstract：INTRODUCTION:Spironolactone is increasingly being used in the treatment of heart failure. However, it has been associated with cases of hyperkalaemia. The common use of angiotensin-converting enzyme (ACE) inhibitors and angiotensin-2 receptor (AT2) antagonists in heart failure increases the risk of hyperkalaemia. OBJE...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Anton C,Cox AR,Watson RD,Ferner RE

更新日期：2003-08-01 00:00:00

abstract：OBJECTIVE:A large number of structurally and functionally diverse compounds act as substrates or modulators of p-glycoprotein (p-gp). Some of them possess multiple drug resistance (MDR)-reversing activity, but only a small number of them have entered clinical study. In order to uncover the factors which exert a signifi...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Wang RB,Kuo CL,Lien LL,Lien EJ

更新日期：2003-06-01 00:00:00

abstract：OBJECTIVE:To compare the efficacy of 500 mg ornidazole vaginal ovules (VO) and vaginal tablets (VT) in the treatment of bacterial vaginosis. METHOD:Patients were allocated at random to one group of 50 subjects to be treated with a VO (500 mg) prepared in our laboratory and to a second group of 50 subjects to be treate...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Baloğlu E,Ozyazici M,Baloğlu A,Ova L

更新日期：2003-04-01 00:00:00

abstract：OBJECTIVES:The use of psychotropic drugs has increased continuously over recent years in industrialized countries. In Europe, France has the highest consumption of such drugs. The aim of this study was to identify the sociodemographic and medical factors associated with the use of psychotropic agents. METHODS:Data, co...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Empereur F,Baumann M,Alla F,Briançon S

更新日期：2003-02-01 00:00:00

abstract：:The efficacy of a novel, proprietary topical formulation of ibuprofen 5% gel (Ibugel) and ibuprofen 400 mg tablets (1200 mg daily) was compared in a double-blind, double-dummy, parallel group study in patients with acute soft tissue injuries. Patients received either active gel plus placebo tablets (n = 50) or active ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Whitefield M,O'Kane CJ,Anderson S

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:There is evidence that patients are being prescribed potentially hazardous drug-drug combinations in general practice despite the use of computerized drug interaction alert systems. One reason for this may be that general practitioners (GPs) are overriding these alerts without properly checking them. AIMS:(...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Magnus D,Rodgers S,Avery AJ

更新日期：2002-10-01 00:00:00

abstract：OBJECTIVE:Although the elimination half-life of most glucocorticoids is short, they are usually administered once daily, or even on alternate days. Our hypothesis was that this practice might compromise the immunosuppressive effect of those drugs during the second part of the administration interval. METHODS:Eight hea...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Uhl A,Czock D,Boehm BO,Zellner D,Mertz A,Keller F

更新日期：2002-08-01 00:00:00

abstract：:The prevailing major theory of Alzheimer's disease (AD) is that insoluble amyloid beta-peptide (Abeta) found in the cerebral plaques characteristic of the disease is causative or is at least a contributing factor. According to this theory, inhibition of aberrant Abeta production should prevent or at least limit the ex...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Maiorini AF,Gaunt MJ,Jacobsen TM,McKay AE,Waldman LD,Raffa RB

更新日期：2002-06-01 00:00:00

abstract：OBJECTIVE:To assess the usefulness of dynamic laser scattering for monitoring the stability of ampicillin after reconstitution from commercially available vials with respect to the polymer formation and potency. METHODS:Polymer formation and the remaining potency of the reconstituted ampicillin solution were estimated...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Sendo T,Teshima D,Makino K,Mishima K,Itoh Y,Oishi R

更新日期：2002-04-01 00:00:00

abstract：OBJECTIVE:To probe the pharmacokinetic basis for the use of levofloxacin for complicated skin and skin-structure infections (SSSIs) at a once-daily dosage of 750 mg by investigating its penetration into skin tissue. METHOD:Ten healthy volunteers were administered three oral, once-daily 750 mg doses of levofloxacin, an...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Chow AT,Chen A,Lattime H,Morgan N,Wong F,Fowler C,Williams RR

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND:Ropivacaine hydrochloride (HCl) ('Naropin') is a long-acting local anaesthetic agent, administered epidurally to patients undergoing various surgical procedures. A combination of local anaesthetic and opioid is often administered for the management of severe pain to ensure that a minimal dose of each is used...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Oster Svedberg K,McKenzie J,Larrivee-Elkins C

更新日期：2002-02-01 00:00:00

abstract：OBJECTIVE:To investigate the contribution of patient and doctor characteristics in explaining observed variations in prescribing costs between individual doctors. METHOD:Secondary analysis of data collected from general practitioners, Family Health Services Authorities, 1991 Census data set and the Prescription Pricin...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Gill PS,Roalfe A

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:Boric acid is generally not recognized as a poisonous substance. However, boric acid has potentially fatal actions such as hypotension, metabolic acidosis and oliguria. Death may result from circulation collapse and shock. OBJECTIVE:We present a clinical case history of the successful use of forced diuresis...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Teshima D,Taniyama T,Oishi R

更新日期：2001-10-01 00:00:00

abstract：OBJECTIVE:To find out in child abusing mothers whether aggressiveness in general, but which is directed towards their children in particular, could be reduced by giving lithium. METHOD:An open trial of lithium in eight child-abusing mothers. Assessment of aggression using Yudofsky's Overt Aggression Scale. RESULTS:Th...

journal_title：Journal of clinical pharmacy and therapeutics

authors： do Prado-Lima P,Knijnik L,Juruena M,Padilla A

更新日期：2001-08-01 00:00:00

abstract：OBJECTIVES:To determine the effects of temperature on binding characteristics of phenytoin to serum proteins in paediatric patients with epilepsy. METHOD:Serum samples examined in the study were obtained from 41 paediatric patients (23 male, 18 female) with epilepsy on phenytoin monotherapy. Their age ranged from 1 to...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Kodama H,Kodama Y,Itokazu N,Shinozawa S,Kanemaru R,Sugimoto T

更新日期：2001-06-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of the reconstitution methods for the commercial amphotericin B preparation with respect to particulate contamination. METHODS:The particle counts in amphotericin B solutions reconstituted according to three different methods and amphotericin B fluids made with intravenous fluids af...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Sendo T,Hirakawa M,Makino K,Nakashima K,Kataoka Y,Oishi R

更新日期：2001-04-01 00:00:00

abstract：BACKGROUND:The anti-craving drug, naltrexone, is used as a pharmacotherapeutic adjunct in the treatment of alcohol dependence. In addictive disorders, compliance issues remain central. There are limited data on compliance with naltrexone treatment regimens within formalized rehabilitation programs and even less data th...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Feeney GF,Connor JP,Young RM,Tucker J,Czajkowski F

更新日期：2001-02-01 00:00:00

abstract：OBJECTIVES:Assessment of mean 24 h oestradiol (E2) and oestrone (E1) concentration and basic FSH secretion in postmenopausal asthmatic women, before and after HRT use, and to identify any connections between changes in hormone concentrations and patients' clinical state. SUBJECTS:Postmenopausal women (55 asthmatic and...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Kos-Kudła B,Ostrowska Z,Marek B,Ciesielska-Kopacz N,Sieminska L,Kajdaniuk D,Nowak M,Kudla M

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:Although they originated from China, Malays have undergone a lot of intermarriages. A study suggested that CYP2D6 poor metabolism (PM) phenotype was more common in Malays compared to Chinese. CYP2D6 is highly polymorphic and is involved in the metabolism of many drugs and has been implicated in some environm...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Ismail R,Hussein A,Teh LK,Nizam Isa M

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:In early breast cancer patients the transformed epithelial cells are thought to be sensitive to transforming growth factor beta1 (TGFbeta1)-mediated growth arrest. TGFbeta1 may therefore act as an anti-tumour promoter. However, in advanced breast cancer resistance to such TGFbeta1 action develops. Neoplastic...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Kajdaniuk D,Marek B,Swietochowska E,Ostrowska Z,Glogowska-Szelag J,Kos-Kudla B,Ciesielska-Kopacz N,Wielkoszyski T

更新日期：2000-08-01 00:00:00

abstract：:Otitis media occurs commonly in children, and is usually treated with an antibiotic. In this case report, amoxicillin was prescribed for a 6-year-old boy suffering from acute otitis media. As he had previously experienced a rash after the administration of a penicillin, the medication order was switched from amoxicill...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Falconer CL,Gardner DM

更新日期：2000-06-01 00:00:00

abstract：OBJECTIVE:Studies on antiepileptic drug utilization are important for the optimization of drug therapy and drug control. The present study was to evaluate the drug utilization pattern of standard antiepileptic drugs and traditional Chinese medicines (TCMs) in the treatment of different types of epilepsy in a general ho...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Chen LC,Chen YF,Yang LL,Chou MH,Lin MF

更新日期：2000-04-01 00:00:00

abstract：:The subject of 'drug addiction' is multifaceted and many aspects of it (even some of the definitions) are controversial. Collateral medical problems include the spread of HIV and hepatitis C virus secondary to i.v. drug abuse and effects on prenatal brain development (1). Progress in the understanding of the causes of...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Betz C,Mihalic D,Pinto ME,Raffa RB

更新日期：2000-02-01 00:00:00

abstract：OBJECTIVE:There is a growing interest in investigating the role of glutamate receptors in the pathophysiology of schizophrenia. Indeed, the hyperdopaminergic theory of schizophrenia can explain only the positive symptoms of schizophrenia, whereas the glutamate hypothesis may provide a more comprehensive view of the ill...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Noorbala AA,Akhondzadeh S,Davari-Ashtiani R,Amini-Nooshabadi H

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Information about the pharmacokinetics of digoxin in paediatric patients is limited. We therefore aimed to investigate the effects of physiological factors on the digoxin clearance in Japanese paediatric patients. METHOD:We used routinely collected therapeutic drug monitoring data (n=544), de...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Suematsu F,Minemoto M,Yukawa E,Higuchi S

更新日期：1999-06-01 00:00:00

abstract：:Pharmacokinetic interactions between antiepileptics represent a major potential complication of epilepsy treatment because drug combinations are common. This review discusses pharmacokinetic drug interactions of clinical significance involving antiepileptics and cytochrome P450 (CYP). Most commonly used antiepileptics...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Tanaka E

更新日期：1999-04-01 00:00:00

abstract：OBJECTIVE:A population analysis of the kinetics of valproic acid (VPA) in children with epilepsy was performed in order to characterize the covariates which influence VPA clearance (CL). METHODS:A total of 770 steady-state serum concentration samples was analysed. These were collected during VPA therapy from 255 child...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Serrano BB,García Sánchez MJ,Otero MJ,Buelga DS,Serrano J,Domínguez-Gil A

更新日期：1999-02-01 00:00:00

abstract：:A number of drugs have been reported to cause neuromuscular blockade and/or to increase weakness in myasthenia gravis. We report on two patients, treated with felodipine and nifedipine for arterial hypertension, who presented with an exacerbation of their myasthenia gravis and a myasthenic syndrome or exacerbation of ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Pina Latorre MA,Cobeta JC,Rodilla F,Navarro N,Zabala S

更新日期：1998-10-01 00:00:00

abstract：:Recent reports of interactions between alcohol and benzodiazepines, tricyclic and tetracyclic antidepressants during their acute concomitant use are reviewed. Acute ingestion of alcohol (ethanol) with tranquilizers or hypnotics is responsible for several pharmacokinetic interactions that can have significant clinical ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Tanaka E,Misawa S

更新日期：1998-10-01 00:00:00

abstract：:Very few studies have been carried out looking at how the effects of drugs and their toxicity in humans change during their lifespan (developing and ageing). The purpose of this study is to review the literature on the changes in probe-drug metabolism, classified by cytochrome P450 (P450 or CYP) at five stages in life...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Tanaka E

更新日期：1998-08-01 00:00:00

abstract：OBJECTIVE:To compare aminoglycoside pharmacokinetics in African-Americans with normal renal function with published adult population values. DESIGN:An Institutional Review Board approved concurrent study. SETTING:The study was conducted at Howard University Hospital, Washington DC. SUBJECTS:All subjects had serum cr...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Oparaoji EC,Siram S,Elemihe U,Mezghebe HM,Cho T,Bashiri M,Piedrahita K,Pipalla RS

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:Therapeutic drug monitoring of clozapine as an aid in the treatment of schizophrenic states is commonly used in our hospital. OBJECTIVE:Development of a high-performance liquid chromatographic method for the determination of clozapine (CLZ) and its major metabolite desmethylclozapine (DMCLZ) in plasma and s...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Dumortier G,Lochu A,Zerrouk A,Van Nieuwenhuyse V,Colen de Melo P,Roche Rabreau D,Degrassat K

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Vancomycin is often used in antibiotic infusions for hospitalized patients and it is advantageous to prepare such intravenous solutions in advance. The objective of this study was to investigate the long-term stability of this antibiotic stored at 4 degrees C in polyvinyl chloride (PVC) bags. ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Galanti LM,Hecq JD,Vanbeckbergen D,Jamart J

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Morphine hydrochloride, a major analgesic drug, is being increasingly administered using portable disposable infusion devices. The objective of this study was to investigate the stability of morphine in such a system at two concentrations (2.50 and 5.00 mg/ ml) over a 30-day period. METHOD:Hig...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Oustric-Mendes AC,Huart B,Le Hoang MD,Perrin-Rosset M,Pailler FM,Darbord JC,Prognon P,Gard C,Pradeau D

更新日期：1997-08-01 00:00:00

abstract：:The stability and compatibility of anakinra (recombinant human interleukin-1 receptor antagonist) with ceftriaxone sodium in 0.9% sodium chloride or 5% dextrose injection was determined during a 4-h period at ambient room temperature and light. Anakinra was diluted in 0.9% sodium chloride or 5% dextrose to the concent...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Nahata MC,Morosco RS,Sabados BK,Weber TR

更新日期：1997-06-01 00:00:00

abstract：AIM:Some studies have indicated that over-reliance on inhaled bronchodilator (beta 2-agonist) therapy may worsen asthma control and increase morbidity. The aim of this study was to measure urinary concentrations of salbutamol, the most commonly used bronchodilator, in a relatively large sample of asthmatic patients and...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Jacobson GA,Peterson GM,McLean S

更新日期：1997-04-01 00:00:00